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Answers:    Depends on the length of time they're away from globe.

1) Cardiovascular effects

Humans on Earth are affected by gravity - around two-thirds of our daily events are standing or sitting. Because of this great amounts of body fluids such as blood pool in the lower section of the body. The human body is equipped with a variety of mechanisms to deny gravity and maintain sufficient blood flow to the brain.

In a zero-g environment, the level and the distribution of body fluid is altered since it is free of the gravitational effect. This is the known as "fluid shift." Symptoms cause by fluid shift are stuffy nose, headache, and puffy frontage.

2) Effects on bone

The adult human body have 1,000 to 1,200 grams of calcium and 400 to 500 grams of phosphorus in bone. However, once gravitational stress is removed, bone calcium and phosphorus are excessively excreted contained by urine and feces. Tests have shown that 3.2% bone loss occur after nearly 10 days of weightlessness. The loss of calcium within urine may produce urinary stones, which might cause severe aching, and the decrease of bone density will front to bone fracture.

Countermeasures are necessary to prevent bone loss - onboard exercise by and large with the treadmill and ergo meter.

3) Effects on muscle

In a micro gravity environment, muscles hurriedly weaken due to the dearth of use.

4) Space motion sickness

Sixty to seventy percent of astronauts experience space motion sickness, characterized by headaches, malaise, nausea and vomiting after as little as a few minutes or a few hours after entering flimsiness.

5) Hematologic and immunologic system effects

In weightlessness, some red blood cell transform into spherical shapes instead of remaining biconcave discoidal (i.e., doughnuts without a hole). However, they are readily reversed even after long-term space missions.

6) Space radiation effects

On Earth, the atmosphere and enigmatic field provide a shield for humans and prevent radiation from thorough to the Earth's surface. Due to the absence of such shielding surrounded by the space environment, astronauts are subjected to greater amounts of space radiation than they would receive on the Earth. This may seriously affect astronauts.

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