What is Nordihydraguaiaretic Acid?
Answers: nordihydroguaiaretic acid
A readily occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic happenings. Nordihydroguaiaretic acid (NDGA) directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting within decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis within susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association next to the activation of stress activated protein kinases (SAPKs). In adjunct, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting surrounded by diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at highly developed concentrations, may also inhibit cyclooxygenase
NDGA is a non-selective lipoxygenase inhibitor which blocks cysteinyl-leukotriene (CysLT) synthesis.
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